A Statistical Analysis of Supersymmetric Dark Matter in the MSSM after WMAP

We study supersymmetric dark matter in the general flavor diagonal MSSM by means of an extensive random scan of its parameter space. We find that, in contrast with the standard mSUGRA lore, the large majority of viable models features either a higgsino or a wino-like lightest neutralino, and yields a relic abundance well below the WMAP bound. Among the models with neutralino relic density within the WMAP range, higgsino-like neutralinos are still dominant, though a sizeable fraction of binos is also present. In this latter case, relic density suppression mechanisms are shown to be essential in order to obtain the correct neutralino abundance. We then carry out a statistical analysis and a general discussion of neutralino dark matter direct detection and of indirect neutralino detection at neutrino telescopes and at antimatter search experiments. We point out that current data exclude only a marginal portion of the viable parameter space, and that models whose thermal relic abundance lies in the WMAP range will be significantly probed only at future direct detection experiments. Finally, we emphasize the importance of relic density enhancement mechanisms for indirect detection perspectives, in particular at future antimatter search experiments.Comment: 39 pages, 25 figure

Relic Neutralino Densities and Detection Rates with Nonuniversal Gaugino Masses

We extend previous analyses on the interplay between nonuniversalities in the gaugino mass sector and the thermal relic densities of LSP neutralinos, in particular to the case of moderate to large tan beta. We introduce a set of parameters that generalizes the standard unified scenario to cover the complete allowed parameter space in the gaugino mass sector. We discuss the physical significance of the cosmologically preferred degree of degeneracy between charginos and the LSP and study the effect this degree of degeneracy has on the prospects for direct detection of relic neutralinos in the next round of dark matter detection experiments. Lastly, we compare the fine tuning required to achieve a satisfactory relic density with the case of universal gaugino masses, as in minimal supergravity, and find it to be of a similar magnitude. The sensitivity of quantifiable measures of fine-tuning on such factors as the gluino mass and top and bottom masses is also examined.Comment: Uses RevTeX; 14 pages, 16 figure

Phenomenological Implications of Deflected Mirage Mediation: Comparison with Mirage Mediation

We compare the collider phenomenology of mirage mediation and deflected mirage mediation, which are two recently proposed "mixed" supersymmetry breaking scenarios motivated from string compactifications. The scenarios differ in that deflected mirage mediation includes contributions from gauge mediation in addition to the contributions from gravity mediation and anomaly mediation also present in mirage mediation. The threshold effects from gauge mediation can drastically alter the low energy spectrum from that of pure mirage mediation models, resulting in some cases in a squeezed gaugino spectrum and a gluino that is much lighter than other colored superpartners. We provide several benchmark deflected mirage mediation models and construct model lines as a function of the gauge mediation contributions, and discuss their discovery potential at the LHC.Comment: 29 pages, 9 figure

TeV Symmetry and the Little Hierarchy Problem

Constraints from precision electroweak measurements reveal no evidence for new physics up to 5 - 7 TeV, whereas naturalness requires new particles at around 1 TeV to address the stability of the electroweak scale. We show that this "little hierarchy problem" can be cured by introducing a symmetry for new particles at the TeV scale. As an example, we construct a little Higgs model with this new symmetry, dubbed T-parity, which naturally solves the little hierarchy problem and, at the same time, stabilize the electroweak scale up to 10 TeV. The model has many important phenomenological consequences, including consistency with the precision data without any fine-tuning, a stable weakly-interacting particle as the dark matter candidate, as well as collider signals completely different from existing little Higgs models, but rather similar to the supersymmetric theories with conserved R-parity.Comment: 15 pages, 1 figure; v.2: typos corrected and various minor modifications/expansions on the presentations. now 16 pages and 1 figure. version to appear on JHE

Direct detection of neutralino dark matter in supergravity

The direct detection of neutralino dark matter is analysed in general supergravity scenarios, where non-universal soft scalar and gaugino masses can be present. In particular, the theoretical predictions for the neutralino-nucleon cross section are studied and compared with the sensitivity of dark matter detectors. We take into account the most recent astrophysical and experimental constraints on the parameter space, including the current limit on B(Bs-> mu+ mu-). The latter puts severe limitations on the dark matter scattering cross section, ruling out most of the regions that would be within the reach of present experiments. We show how this constraint can be softened with the help of appropriate choices of non-universal parameters which increase the Higgsino composition of the lightest neutralino and minimise the chargino contribution to the b->s transition.Comment: 27 pages, 22 figure

uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion

The uptake and lysosomal degradation of collagen by fibroblasts constitute a major pathway in the turnover of connective tissue. However, the molecular mechanisms governing this pathway are poorly understood. Here, we show that the urokinase plasminogen activator receptor–associated protein (uPARAP)/Endo180, a novel mesenchymally expressed member of the macrophage mannose receptor family of endocytic receptors, is a key player in this process. Fibroblasts from mice with a targeted deletion in the uPARAP/Endo180 gene displayed a near to complete abrogation of collagen endocytosis. Furthermore, these cells had diminished initial adhesion to a range of different collagens, as well as impaired migration on fibrillar collagen. These studies identify a central function of uPARAP/Endo180 in cellular collagen interactions

MT1-matrix metalloproteinase directs arterial wall invasion and neointima formation by vascular smooth muscle cells

During pathologic vessel remodeling, vascular smooth muscle cells (VSMCs) embedded within the collagen-rich matrix of the artery wall mobilize uncharacterized proteolytic systems to infiltrate the subendothelial space and generate neointimal lesions. Although the VSMC-derived serine proteinases, plasminogen activator and plasminogen, the cysteine proteinases, cathepsins L, S, and K, and the matrix metalloproteinases MMP-2 and MMP-9 have each been linked to pathologic matrix-remodeling states in vitro and in vivo, the role that these or other proteinases play in allowing VSMCs to negotiate the three-dimensional (3-D) cross-linked extracellular matrix of the arterial wall remains undefined. Herein, we demonstrate that VSMCs proteolytically remodel and invade collagenous barriers independently of plasmin, cathepsins L, S, or K, MMP-2, or MMP-9. Instead, we identify the membrane-anchored matrix metalloproteinase, MT1-MMP, as the key pericellular collagenolysin that controls the ability of VSMCs to degrade and infiltrate 3-D barriers of interstitial collagen, including the arterial wall. Furthermore, genetic deletion of the proteinase affords mice with a protected status against neointimal hyperplasia and lumen narrowing in vivo. These studies suggest that therapeutic interventions designed to target MT1-MMP could prove beneficial in a range of human vascular disease states associated with the destructive remodeling of the vessel wall extracellular matrix

T-parity, its problems and their solution

We point out a basic difficulty in the construction of little-Higgs models with T-parity which is overlooked by large part of the present literature. Almost all models proposed so far fail to achieve their goal: they either suffer from sizable electroweak corrections or from a breakdown of collective breaking. We provide a model building recipe to bypass the above problem and apply it to build the simplest T-invariant extension of the Littlest Higgs. Our model predicts additional T-odd pseudo-Goldstone bosons with weak scale masses.Comment: 25 pages, 2 appendice

Activation and localization of matrix metalloproteinase-2 and -9 in the skeletal muscle of the muscular dystrophy dog (CXMDJ)

<p>Abstract</p> <p>Background</p> <p>Matrix metalloproteinases (MMPs) are key regulatory molecules in the formation, remodeling and degradation of all extracellular matrix (ECM) components in both physiological and pathological processes in various tissues. The aim of this study was to examine the involvement of gelatinase MMP family members, MMP-2 and MMP-9, in dystrophin-deficient skeletal muscle. Towards this aim, we made use of the canine X-linked muscular dystrophy in Japan (CXMD_J) model, a suitable animal model for Duchenne muscular dystrophy.</p> <p>Methods</p> <p>We used surgically biopsied tibialis cranialis muscles of normal male dogs (n = 3) and CXMD_Jdogs (n = 3) at 4, 5 and 6 months of age. Muscle sections were analyzed by conventional morphological methods and <it>in situ </it>zymography to identify the localization of MMP-2 and MMP-9. MMP-2 and MMP-9 activity was examined by gelatin zymography and the levels of the respective mRNAs in addition to those of regulatory molecules, including MT1-MMP, TIMP-1, TIMP-2, and RECK, were analyzed by semi-quantitative RT-PCR.</p> <p>Results</p> <p>In CXMD_Jskeletal muscle, multiple foci of both degenerating and regenerating muscle fibers were associated with gelatinolytic MMP activity derived from MMP-2 and/or MMP-9. In CXMD_Jmuscle, MMP-9 immunoreactivity localized to degenerated fibers with inflammatory cells. Weak and disconnected immunoreactivity of basal lamina components was seen in MMP-9-immunoreactive necrotic fibers of CXMD_Jmuscle. Gelatinolytic MMP activity observed in the endomysium of groups of regenerating fibers in CXMD_Jdid not co-localize with MMP-9 immunoreactivity, suggesting that it was due to the presence of MMP-2. We observed increased activities of pro MMP-2, MMP-2 and pro MMP-9, and levels of the mRNAs encoding MMP-2, MMP-9 and the regulatory molecules, MT1-MMP, TIMP-1, TIMP-2, and RECK in the skeletal muscle of CXMD_Jdogs compared to the levels observed in normal controls.</p> <p>Conclusion</p> <p>MMP-2 and MMP-9 are likely involved in the pathology of dystrophin-deficient skeletal muscle. MMP-9 may be involved predominantly in the inflammatory process during muscle degeneration. In contrast, MMP-2, which was activated in the endomysium of groups of regenerating fibers, may be associated with ECM remodeling during muscle regeneration and fiber growth.</p